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All pulmonology trends
RisingPulmonology · updated 18 Oct 2026

Antifibrotics in pulmonary fibrosis

Nintedanib, pirfenidone and newer antifibrotics.

64PubDaily Trend Score
+18%new papers vs last year
23new trials registered
1new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 17, 12, 19, 12, 23.

New guidelines and consensus this year

  1. Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): An Official 2025 ALAT Clinical Practice Guideline
    Arch Bronconeumol2026 Apr 10

All papers from the last 12 months

511 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

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  1. Fibronectin's tensional state as a mechanical signature of fibrotic extracellular matrix in idiopathic pulmonary fibrosis models
    Matrix Biol Plus2026 DecPMID 42730024
  2. Spatial distribution of fibroblastic foci in transbronchial lung cryobiopsy specimens
    Ann Diagn Pathol2026 DecPMID 42636713
  3. Statin use and its implications on survival and disease progression in the European MultiPartner idiopathic pulmonary fibrosis registry (EMPIRE)
    Ann Med2026 DecPMID 41852279
  4. Multi-omics reveals the effects and mechanisms of Xinxue Granules against idiopathic pulmonary fibrosis through activating the cAMP/EPAC/CREB axis
    J Ethnopharmacol2026 Nov 15PMID 42302945
  5. Targeting the Snail1-ATGL-ferroptosis-EMT axis via AKT-GSK3β signaling: Low-dose colchicine attenuates idiopathic pulmonary fibrosis
    Eur J Pharmacol2026 Nov 10PMID 42785459
  6. Novel therapies for refractory idiopathic inflammatory myopathy-associated interstitial lung disease
    Curr Opin Rheumatol2026 Nov 1PMID 42712119Review
  7. Inhalation therapies in interstitial lung diseases
    Expert Opin Drug Deliv2026 Oct 15PMID 42858239Review
  8. Structure based identification of novel 4,5,6,7-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one derivatives as nonacidic ATX inhibitors with promising antifibrotic effects
    Eur J Med Chem2026 Oct 15PMID 42224938
  9. Tofacitinib in rheumatoid arthritis-associated interstitial lung disease: immunomodulation and antifibrotic therapy as complementary strategies?
    Respir Med2026 Oct 14PMID 42874937
  10. Interstitial lung disease as the initial manifestation of systemic autoimmune disease: a narrative review of autoantibodies, biomarkers, prognosis, and management
    Clin Exp Rheumatol2026 Oct 13PMID 42873695Review

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

("progressive pulmonary fibrosis"[tiab] OR "idiopathic pulmonary fibrosis"[tiab]) AND (nintedanib[tiab] OR pirfenidone[tiab] OR nerandomilast[tiab] OR antifibrotic*[tiab])

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.