Disease-modifying osteoarthritis drugs
Drugs studied to change the course of osteoarthritis, including GLP-1 drugs.
Key point
Given current data, conventional synthetic or biological disease-modifying anti-rheumatic drugs are not advised for people living with hand osteoarthritis.
From: French Societies of Rheumatology and of Physical and Rehabilitation Medicine recommendations for the management of people living with hand osteoarthritis (Joint Bone Spine, 2026 Mar) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 3, 7, 4, 4, 8.
New guidelines and consensus this year
- Joint TOS/OMA/OAC Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the GRADE ApproachObesity (Silver Spring)2026 Apr
- French Societies of Rheumatology and of Physical and Rehabilitation Medicine recommendations for the management of people living with hand osteoarthritisJoint Bone Spine2026 Mar
All papers from the last 12 months
487 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- From pathogenic to reparative: Context-Dependent function of extracellular vesicles in osteoarthritisBioact Mater2027 FebPMID 42741701Review
- PRP-activating hyaluronic acid hydrogels for immune-modulatory osteoarthritis repairBioact Mater2027 FebPMID 42741686
- Protease-shielded PRG4 self-amplifying RNA lipid nanoparticles restore cartilage homeostasis in osteoarthritisBiomaterials2027 FebPMID 42679542
- Molecular hydrogen and osteoarthritis: multi-target mechanisms and therapeutic effectivenessMed Gas Res2027 Jan 1PMID 42734458Review
- Geometrically adaptive hydrogel attenuates osteoarthritis via metabolic reprogramming and defect sealingBiomaterials2027 JanPMID 42526197
- Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritisGut Microbes2026 Dec 31PMID 42231528
- Glucagon-like peptide-1: a critical link between gut microbiota dysbiosis and degenerative musculoskeletal diseasesGut Microbes2026 Dec 31PMID 42021124Review
- Nanoimmunomodulation for cartilage repair in osteoarthritis: reprogramming the inflammatory joint microenvironmentInt J Pharm X2026 DecPMID 42725019Review
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunitiesJ Transl Autoimmun2026 DecPMID 42668582Review
- A stiffness-tunable 3D alginate-collagen-hyaluronic acid model reveals the matrix-dependent chondroprotection of quercetin in osteoarthritisBiomater Adv2026 DecPMID 42641414
More orthopedics trends
All specialties →AI fracture detection
AI that detects fractures on radiographs.
Key point: AI assistance significantly improves clinicians' diagnostic performance in detecting extremity and trunk fractures on radiographs.
3D-printed and patient-specific implants
3D printing and patient-specific implants in orthopaedics.
Periprosthetic joint infection
Diagnosis and treatment of infection after joint replacement.
Key point: Suppressive antimicrobial therapy for periprosthetic joint infection had pooled reported success rates of 74% after acute DAIR and 70% in chronic cases.
Robotic joint replacement
Robot-assisted knee and hip arthroplasty.
Platelet-rich plasma
PRP injections for osteoarthritis and tendon problems.
Endoscopic spine surgery
Full-endoscopic and biportal endoscopic spine surgery.
Key point: PIED, PTED, and UBE all provide effective decompression for lumbar lateral recess stenosis, with PTED showing the most consistent symptom improvement, safety, and efficiency.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
osteoarthritis[tiab] AND (semaglutide[tiab] OR "GLP-1"[tiab] OR sprifermin[tiab] OR lorecivivint[tiab] OR "disease-modifying"[tiab])Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.