Primary aldosteronism
Screening, diagnosis and treatment of primary aldosteronism.
Key point
Universal screening for primary aldosteronism in all patients with hypertension with an aldosterone-to-renin ratio test is now recommended.
From: Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratory (Pathology, 2026 Aug) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 14, 26, 30, 18, 29.
New guidelines and consensus this year
- Primary aldosteronism: Interpreting the 2025 Endocrine Society clinical practice guideline updateCleve Clin J Med2026 Sep 1
- Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratoryPathology2026 Aug
- Update of the guidelines on the management of adrenal incidentaloma from the adrenal group of the Spanish society of endocrinology and nutrition (SEEN)Endocrine2025 Nov
All papers from the last 12 months
575 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Gut microbiota signatures in primary aldosteronism and functional identification of an aldosterone-degrading gut bacteriumGut Microbes2026 Dec 31PMID 41964107
- Clinical implications of aldosterone responsiveness to adrenocorticotropic hormone stimulation in two major subtypes of primary aldosteronismClin Exp Hypertens2026 Dec 31PMID 41761656
- Adrenocortical oncocytoma manifesting as primary aldosteronism: a case reportBlood Press2026 DecPMID 42439312
- An unexpected finding of apparent bilateral aldosterone suppression after superselective adrenal venous sampling: a case reportBlood Press2026 DecPMID 42165404
- Hypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort studyBlood Press2026 DecPMID 41852294
- Secondary causes and renal outcomes in apparently resistant hypertension: a retrospective cohort studyBlood Press2026 DecPMID 41504217
- Coexisting adrenal hemangioma and aldosterone-producing micronodule presented as adrenal incidentalomaJCEM Case Rep2026 NovPMID 42871030
- A Ten Year Overview of Adrenal Vein Sampling in Croatia: Insights and OutcomesClin Endocrinol (Oxf)2026 NovPMID 42521476
- Cytosolic calcium oscillations in human adrenocortical cells causing primary aldosteronismMol Cell Endocrinol2026 NovPMID 42431251
- Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cellsBiochem Biophys Res Commun2026 Oct 29PMID 42777615
More endocrinology trends
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Triple agonists and amylin combinations such as retatrutide and CagriSema.
Key point: CagriSema led to a greater proportion of adults with obesity achieving BMI and waist-to-height ratio targets than semaglutide, cagrilintide, or placebo.
Oral GLP-1 drugs
Oral semaglutide and small-molecule GLP-1 agonists such as orforglipron.
Key point: In adults with obesity or overweight and type 2 diabetes, once-daily orforglipron reduced bodyweight versus placebo, with safety similar to other GLP-1 agonists.
Automated insulin delivery
Hybrid closed-loop systems that adjust insulin automatically.
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Key point: IGF-1R inhibitors outperformed placebo across multiple thyroid eye disease efficacy outcomes, particularly in active disease, but increased adverse-event risk warrants vigilant monitoring.
CGM in type 2 diabetes
Continuous glucose monitoring for people with type 2 diabetes.
Key point: CGM is strongly recommended for people with type 2 diabetes treated with insulin and those not treated with insulin, particularly when HbA1c is ≥7%.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
"primary aldosteronism"[tiab]Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.