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All cardiology trends
Rising fastCardiology · updated 18 Oct 2026

Tirzepatide in cardiovascular disease

Research on tirzepatide, a dual GIP/GLP-1 receptor agonist, and heart and vascular outcomes.

92PubDaily Trend Score
+91%new papers vs last year
42new trials registered
7new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 1, 4, 9, 29, 42.

New guidelines and consensus this year

  1. Incretin-based therapies in peri- and postmenopausal women with obesity: an expert position statement from the Spanish Menopause Society
    Maturitas2026 Oct
  2. Pharmacologic Treatments With Lifestyle Modifications in Nonpregnant Adults With Overweight or Obesity in Outpatient Settings: A Living Clinical Guideline From the American College of Physicians (April 2026)
    Ann Intern Med2026 Aug
  3. Swiss obesity clinical practice guidance
    Swiss Med Wkly2026 May 19
  4. [Individualizing antihypertensive therapy in diabetes mellitus. Guidelines of the Austrian Diabetes Association (Update 2026)]
    Wien Klin Wochenschr2026 May
  5. Joint TOS/OMA/OAC Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the GRADE Approach
    Obesity (Silver Spring)2026 Apr

All papers from the last 12 months

395 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

Open this search in PubMed
  1. Cardiovascular outcomes with tirzepatide versus semaglutide in type 2 diabetes
    J Diabetes Metab Disord2026 DecPMID 42840232
  2. Incretin therapy prescription in a high cardiovascular risk population: Insights from a cardiology-based cardiometabolic program
    Am J Prev Cardiol2026 DecPMID 42828252
  3. Association of tirzepatide with reverse cardiac remodeling and improved diastolic function in obesity-related HFpEF: A prospective real-world cohort study
    Int J Cardiol2026 Dec 1PMID 42710812
  4. Cost-effectiveness of tirzepatide versus semaglutide for patients with obesity or overweight in the US: evidence from the SURMOUNT-5 head-to-head phase-3 trial
    J Med Econ2026 DecPMID 42012820
  5. Tirzepatide attenuates cardiac microvascular injury and ferroptosis-related lipid peroxidation in diabetic mice: endothelial responses in the context of partial PRKN silencing
    Eur J Pharmacol2026 Nov 25PMID 42826814
  6. Current review of glucagon-like peptide 1 receptor agonists and risk of nonarteritic anterior ischemic optic neuropathy
    J Endocr Soc2026 NovPMID 42857401Review
  7. Real-world effectiveness of 6-month tirzepatide therapy on body weight and composition in adults with overweight and obesity
    J Diabetes Complications2026 NovPMID 42805130
  8. Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications
    Curr Opin Nephrol Hypertens2026 Nov 1PMID 42683763Review
  9. From adiposity to multisystem morbidity: the case for weight loss as disease modification
    Lancet Diabetes Endocrinol2026 NovPMID 42660161Review
  10. Cardiorenal Mortality and Safety Outcomes of GLP-1 Receptor Agonists in Type 2 Diabetes With BMI Below 27 kg/m(2): A Target Trial Emulation
    Diabetes Obes Metab2026 NovPMID 42642357

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

tirzepatide[tiab] AND (cardiovascular[tiab] OR cardiac[tiab] OR heart[tiab])

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.