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All neurology trends
EmergingNeurology · updated 18 Oct 2026

Alpha-synuclein seed amplification

Seed amplification assays that detect misfolded alpha-synuclein.

47PubDaily Trend Score
+20%new papers vs last year
2new trials registered
0new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 1, 2, 0, 2, 2.

All papers from the last 12 months

116 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

Open this search in PubMed
  1. α-Synuclein Seeds Amplification Assays for Parkinson's Disease and Related Synucleinopathies
    Med Res Rev2026 NovPMID 42460688Review
  2. Consistency of Serial Cerebrospinal Fluid α-Synuclein Seed Amplification Assay Results in the Parkinson's Precision Medicine Initiative
    Mov Disord2026 Oct 12PMID 42865036
  3. From a prion seed to a tree of discoveries: Byron Caughey's RT-QuIC legacy in protein misfolding research
    Acta Neuropathol2026 Oct 7PMID 42842018Review
  4. Neuropsychiatric and Cognitive Symptom Evolution over the First Decade of Biomarker-Positive, Sporadic Parkinson's Disease
    Mov Disord2026 Oct 6PMID 42839627
  5. Study of blood linear RNA nominates CD55 and DLD as early-stage biomarkers for Parkinson's disease
    Brain2026 Oct 5PMID 41525793
  6. Clinical and biomarker predictors of α-synuclein seeding in cognitive impairment and motor parkinsonism
    Parkinsonism Relat Disord2026 Oct 4PMID 42854385
  7. In vivo detection of pathologic α- synuclein and TDP-43 in the skin and olfactory mucosa of a patient with Parkinson's disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation
    Mol Neurodegener2026 Oct 1PMID 42823745
  8. α-Synuclein Seeding Discriminates Between LRRK2 G2019S Variant Carriers with and Without Parkinson's Disease
    Mov Disord2026 Sep 28PMID 42806694
  9. microRNA-7-5p and α-Synuclein SAA Predict Parkinson's Disease Phenoconversion
    Ann Clin Transl Neurol2026 Sep 25PMID 42791197
  10. Urine-Derived Neuronal Extracellular Vesicle α-Synuclein Seed Amplification Assay for Synucleinopathies: A Non-Invasive Biomarker Study
    Mov Disord2026 Sep 21PMID 42768739

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

("seed amplification assay"[tiab] OR "RT-QuIC"[tiab]) AND synuclein[tiab]

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.