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All neurology trends
EmergingNeurology · updated 18 Oct 2026

BTK inhibitors in multiple sclerosis

Bruton's tyrosine kinase inhibitors studied in multiple sclerosis.

46PubDaily Trend Score
+41%new papers vs last year
2new trials registered
0new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 1, 1, 2, 2, 2.

All papers from the last 12 months

52 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

Open this search in PubMed
  1. Multiple sclerosis: Advances in diagnosis, biomarkers, and disease management
    J Neuroimmunol2026 Oct 7PMID 42868862
  2. Utilization of Brain Physiologically Based Pharmacokinetic Modeling in Support of CNS Drug Development: Case Example of Fenebrutinib
    AAPS J2026 Oct 5PMID 42834264
  3. Horizon Scanning of Multiple Sclerosis Expenditure in Italy (2025-2029): Updated Insights from the Oracle Model
    Neurol Ther2026 Oct 3PMID 42828703
  4. Exploring Progressive Multiple Sclerosis and the Therapeutic Potential of BTK Inhibitors Based on EBV-driven B Cell-microglia Interactions
    CNS Neurol Disord Drug Targets2026 Oct 1PMID 42861741
  5. Comparator Event Rates, Baseline Activity, and Operational Selection Pressure in Relapsing Multiple Sclerosis Trials: A Meta-Epidemiological Analysis
    Eur J Neurol2026 OctPMID 42858119Meta-analysis
  6. High-throughput primary B cell cytokines assay for drug screening in multiple sclerosis
    Biomed Pharmacother2026 OctPMID 42697043
  7. Tolebrutinib in nonrelapsing SPMS: regulatory divergence and the limits of relapse based labels
    Mult Scler Relat Disord2026 OctPMID 42567027
  8. B-cell targeting strategies for the treatment of multiple sclerosis: from non-cellular therapies to CAR-engineered cell therapies
    Neurol Sci2026 Sep 24PMID 42782403Review
  9. Tolebrutinib liver safety: A detailed overview
    Mult Scler Relat Disord2026 SepPMID 42546561Review
  10. Targeting progressive multiple sclerosis: Toward mechanism-informed precision medicine
    J Intern Med2026 SepPMID 42482223Review

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

"multiple sclerosis"[tiab] AND ("BTK inhibitor*"[tiab] OR Bruton[tiab] OR tolebrutinib[tiab] OR evobrutinib[tiab] OR fenebrutinib[tiab])

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.