Gene therapy for hearing loss
Gene therapy for genetic deafness, such as OTOF mutations.
Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 2, 7, 3, 3, 6.
New guidelines and consensus this year
All papers from the last 12 months
138 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Exploration of biodistribution of mRNA-delivering lipid nanoparticles in the neonatal mouse inner earInt J Pharm X2026 DecPMID 42861365
- Adenovirus-mediated co-regulation of Notch, FGF and BMP signaling pathways promotes the regeneration of cochlear hair cells in neonatal miceTissue Cell2026 NovPMID 42314533
- Beyond Excitotoxicity: Glutamate-Independent Mechanisms Underlie Noise-Induced Synaptopathy and Compromise Gene Therapy for Hereditary DeafnessMol Ther2026 Oct 16PMID 42888847
- Advances in Stem Cell Therapy for Hearing LossEar Hear2026 Oct 13PMID 42868225
- Otoferlin Gene Therapy: Narrative Review for Ear and Hearing Special Issue: Gene Therapy for Hearing LossEar Hear2026 Oct 13PMID 42868222
- Gene Therapy: Routes of Inner Ear DeliveryEar Hear2026 Oct 13PMID 42868211
- Emerging Therapies for Genetic Deafness: The Rise of Precision Gene EditingEar Hear2026 Oct 13PMID 42868209
- A translational pipeline for classification of variants of uncertain significance to support gene therapy clinical trial in OTOF-related deafnessCell Rep Med2026 Oct 7PMID 42843343
- Breaking the delivery barrier: Advancing gene therapy for adult-onset hearing lossMol Ther2026 Oct 7PMID 42721958
- Efficient and safe transduction of cochlear outer hair cells in adult mice with AAV2.7m8-Myo15Mol Ther2026 Oct 7PMID 42478043
More otorhinolaryngology trends
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Vestibular migraine
Diagnosis and treatment of vestibular migraine.
Hearing loss and dementia
Hearing loss, hearing aids and cognitive decline.
Hypoglossal nerve stimulation
An implanted stimulator for obstructive sleep apnoea.
Key point: In France, hypoglossal nerve stimulation is indicated for non-obese moderate-to-severe OSAHS patients with CPAP or MAD failure or contraindications after mandatory DISE.
Tinnitus
Tinnitus mechanisms and treatments, including neuromodulation.
Cochlear implants
Cochlear implantation, including in older adults and single-sided deafness.
Key point: Cochlear implant indications now include profound unilateral or bilateral sensorineural hearing loss, unilateral deafness, or residual hearing, determined individually for each ear.
Too many papers to read?
PubDaily picks the ones that matter in your specialty and summarises them, about 10 minutes a week.
How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
OTOF[tiab] OR otoferlin[tiab] OR ("hearing loss"[tiab] AND "gene therapy"[tiab])Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.