Gut microbiome and mental health
Links between the gut microbiome and depression or anxiety.
Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 100, 80, 103, 132, 149.
New guidelines and consensus this year
All papers from the last 12 months
1,250 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Gut microbiota on sleep disorders throughout the lifespanMicrobiol Res2027 JanPMID 42735570Review
- Xiaoyao San exerts antidepressant effects via the gut microbiota-brain axis: An integrative fMRI and multiomics studyJ Pharm Biomed Anal2027 Jan 1PMID 42580208
- Vagal sensing of altered gut microbiota links to externalizing behaviorsGut Microbes2026 Dec 31PMID 42860590
- Integrated metagenomic and metabolomic analysis identifies severity-specific inflammatory and metabolic signatures in post-stroke depressionGut Microbes2026 Dec 31PMID 42734183
- From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humansGut Microbes2026 Dec 31PMID 42627212
- Long-term microbiome and clinical effects of a microbiome-guided personalized diet versus low-FODMAP diet in irritable bowel syndrome: A 12-month follow-up randomized controlled trialGut Microbes2026 Dec 31PMID 42623122RCT
- Gut Proteobacteria glycine metabolism regulates neuroplasticity, motivation, and reinstatement of cocaine self-administration in miceGut Microbes2026 Dec 31PMID 42359815
- Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitisGut Microbes2026 Dec 31PMID 42343156
- The effect of probiotic and synbiotic supplementation on sleep parameters in exercised population: a systematic review and synthesis without meta-analysis (SWiM) of randomized controlled trialsJ Int Soc Sports Nutr2026 Dec 31PMID 42184272Systematic review
- Antenatal depressive symptoms impair offspring neurodevelopment by inducing maternal gut microbiota dysbiosis during pregnancyGut Microbes2026 Dec 31PMID 42141775
More psychiatry trends
All specialties →Digital mental health apps
Smartphone apps and digital programmes for depression and anxiety.
Key point: Smartphone-delivered lifestyle medicine reduced depressive symptoms more than waitlist control and maintained within-group improvements through 3-month follow-up in probable depression.
ADHD in adults
Diagnosis and treatment of ADHD in adults.
Loneliness and health
Loneliness and social isolation as risk factors.
Psilocybin therapy
Psilocybin-assisted therapy for depression and other conditions.
Brain stimulation for depression
Transcranial magnetic stimulation, including accelerated theta-burst protocols, for depression.
Key point: Connectivity- or frequency- and connectivity-individualized accelerated iTBS failed to yield significant antidepressant benefits over sham stimulation in treatment-resistant depression.
MDMA-assisted therapy
MDMA combined with psychotherapy, mainly studied in PTSD.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
(microbiome[tiab] OR microbiota[tiab]) AND (depress*[tiab] OR anxiety[tiab] OR psychiatr*[tiab])Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.