Oral step-down for serious infections
Switching to oral antibiotics in endocarditis, bacteraemia and bone infection.
Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 2, 0, 2, 3, 4.
All papers from the last 12 months
59 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific Statement From the American Heart AssociationCirculation2026 Oct 13PMID 42708190Review
- Reducing antibiotic burden in gram-negative bacteraemia: duration optimization and early oral transitionCurr Opin Infect Dis2026 Oct 12PMID 42859849
- Exploring influences on intravenous-to-oral antibiotic switching: a qualitative interview study across healthcare professionsInt J Pharm Pract2026 Oct 5PMID 42832627
- Oral tebipenem pivoxil for complicated urinary tract infections: evidence, potential role in IV-to-oral transition, and antimicrobial stewardshipInfection2026 Oct 3PMID 42828629Review
- Infection-embedded penicillin allergy de-labelling delivers immediate antimicrobial stewardship gains in patients with active infectionJAC Antimicrob Resist2026 OctPMID 42698795
- HOMEFREE: Scaling-Up Evidence-Based Guidelines for IV-to-Oral Antibiotic Switch in Hospitalised Children, an Implementation Study ProtocolJ Paediatr Child Health2026 OctPMID 42557787
- Antibiotic consumption in Europe, 2019-2024: Being AWaRe is not about using lessInt J Antimicrob Agents2026 OctPMID 42315042
- Early versus delayed IV-to-oral antibiotic transition: clinical deterioration after oral switch and variation across regimen pathwaysExpert Rev Anti Infect Ther2026 Sep 9PMID 42690232
- Prescribing patterns of antimicrobial therapy in respiratory tract infections at a tertiary care teaching hospital: a prospective studyMonaldi Arch Chest Dis2026 Sep 3PMID 42695542
- Partial Oral Antibiotic Therapy for Infective Endocarditis: A Practical Review of Current Evidence and GuidelinesPathogens2026 Sep 2PMID 42796692Review
More infectious diseases trends
All specialties →New antibiotics for resistant Gram-negatives
Cefiderocol, sulbactam-durlobactam and other new agents.
Shorter regimens for tuberculosis
Bedaquiline, pretomanid and other shorter TB regimens.
Key point: For adolescents aged 14 years and above and adults with MDR/RR-TB, 6-month BPaLM is recommended over 9-month or longer regimens.
H5N1 avian influenza
H5N1 bird flu in animals and humans.
Dengue
Dengue spread, vaccines and treatment.
Mpox
Mpox epidemiology, vaccination and treatment.
Key point: Paediatric mpox shows variable PCR positivity, progressive skin lesions and fever, with younger children more susceptible to severe complications.
Doxy-PEP
Doxycycline after sex to prevent bacterial sexually transmitted infections.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
("oral step-down"[tiab] OR "partial oral"[tiab] OR "oral switch"[tiab]) AND (antibiotic*[tiab] OR endocarditis[tiab] OR bacteremia[tiab] OR bacteraemia[tiab])Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.