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All hematology trends
SteadyHematology · updated 18 Oct 2026

Paroxysmal nocturnal haemoglobinuria

PNH and new oral complement inhibitors.

10PubDaily Trend Score
-3%new papers vs last year
19new trials registered
0new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 11, 22, 22, 30, 19.

All papers from the last 12 months

188 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

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  1. Real-world pegcetacoplan treatment of paroxysmal nocturnal hemoglobinuria patients with an unsatisfactory response to prior therapies
    Hematology2026 Dec 31PMID 42275288
  2. Case report: persistent anemia after eculizumab in paroxysmal nocturnal hemoglobinuria: non-dominantly active intravascular hemolysis
    Hematology2026 Dec 31PMID 41860373
  3. Recurrent thoracic aortic stent graft thrombosis
    J Vasc Surg Cases Innov Tech2026 DecPMID 42828113
  4. Terminal complement inhibition is associated with renal, hematologic, and thrombotic complications during septic shock: A global propensity score-matched cohort study
    J Crit Care2026 DecPMID 42526359
  5. Switching patients with PNH from pegcetacoplan to iptacopan: a case series
    Hematology2026 DecPMID 41657019
  6. Improvement in anemia and symptoms after switching from crovalimab to iptacopan in paroxysmal nocturnal hemoglobinuria
    Hematology2026 DecPMID 41607343
  7. Cost per responder analysis of iptacopan versus eculizumab and ravulizumab in treatment of paroxysmal nocturnal hemoglobinuria: implications for decision-making
    J Med Econ2026 DecPMID 41518611
  8. Real-world clinical outcomes and treatment response in complement inhibitor experienced and naïve PNH patients prescribed pegcetacoplan in Europe and Canada
    Hematology2026 DecPMID 41480918
  9. Complement targeting in autoimmune diseases
    Curr Opin Hematol2026 Nov 1PMID 42710066Review
  10. Iptacopan combined with immunosuppressive therapy for aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome: A case report
    Medicine (Baltimore)2026 Oct 16PMID 42888561

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

"paroxysmal nocturnal hemoglobinuria"[tiab] OR "paroxysmal nocturnal haemoglobinuria"[tiab]

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.