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All nephrology trends
SteadyNephrology · updated 18 Oct 2026

Pig kidney xenotransplantation

Transplanting genetically modified pig kidneys into humans.

25PubDaily Trend Score
0%new papers vs last year
4new trials registered
0new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 2, 3, 0, 0, 4.

All papers from the last 12 months

113 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

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  1. Is the intraportal or renal subcapsular space a preferable site for islet allo- and xeno-transplantation? A brief historical review
    Islets2026 Dec 31PMID 42017902Review
  2. Xenotransplantation: The Next Surgical Revolution for Acute Liver Failure?
    Ann Surg2026 Nov 1PMID 42675556Review
  3. Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo
    Dev Cell2026 Oct 14PMID 42838060
  4. Bridging the gap: first-in-human pig kidney xenotransplant
    Nat Rev Urol2026 Oct 5PMID 42834172
  5. From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation
    Transplantation2026 Oct 1PMID 42547936Review
  6. Complement system in kidney transplantation: from innate immune surveillance to a therapeutic and genetic engineering target
    Front Immunol2026PMID 42866368Review
  7. Multiomic analyses in xenotransplantation: Hypothesis generation and the path toward precision diagnostics: Vital Insights into Xenotransplantation
    Am J Transplant2026 Sep 23PMID 42777950
  8. Spatial transcriptomic profiling of porcine tissue microarray detecting subclinical circovirus infection
    Front Vet Sci2026PMID 42824453
  9. Kidney xenotransplantation-bridge to allotransplantation or destination treatment?
    Lancet2026 Sep 12PMID 42692039
  10. Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study
    Lancet2026 Sep 12PMID 42692038

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Complement inhibitors in kidney disease

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+38%new papersScore 44
20212026

Iptacopan, avacopan and other complement inhibitors in glomerular disease.

Key point: Complement inhibitors had no overall effectiveness or safety advantage over plasma therapy in atypical hemolytic uremic syndrome, except lower relapse rates.

209 papers / yr6 new trials1 new guideline
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APOL1 kidney disease

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+5%new papersScore 40
20212026

Kidney disease linked to APOL1 gene variants.

127 papers / yr1 new trials1 new guideline
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Home dialysis

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+5%new papersScore 40
20212026

Home haemodialysis and peritoneal dialysis.

Key point: Core interventions to reduce PD-related infections focus on surveillance, standardized staff and patient training, infection prevention assessments, and antimicrobial prophylaxis.

1,458 papers / yr62 new trials9 new guidelines
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HIF-PH inhibitors for anaemia

Steady
-8%new papersScore 33
20212026

Oral drugs such as roxadustat for anaemia of kidney disease.

Key point: HIF-PHIs such as roxadustat are reserved for non-dialysis CKD when erythropoiesis-stimulating agents are unsuitable, given potential risks and limited long-term data.

149 papers / yr9 new trials1 new guideline
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Race-free eGFR

Steady
+1%new papersScore 33
20212026

Kidney function equations without a race coefficient.

151 papers / yr27 new trials
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Potassium binders

Emerging
-20%new papersScore 7
20212026

Patiromer and sodium zirconium cyclosilicate for hyperkalaemia.

Key point: In type 2 diabetes with hyperkalemia, sodium zirconium cyclosilicate did not demonstrate noninferiority to potassium-restricted diet for achieving normokalemia.

60 papers / yr2 new trials
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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

xenotransplant*[tiab] AND (kidney[tiab] OR renal[tiab])

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.