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All gastroenterology trends
RisingGastroenterology · updated 18 Oct 2026

Potassium-competitive acid blockers

Vonoprazan and related acid suppressants.

55PubDaily Trend Score
+21%new papers vs last year
46new trials registered
8new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 27, 28, 30, 37, 46.

New guidelines and consensus this year

  1. Evidence-based clinical practice guidelines for peptic ulcer disease 2026
    J Gastroenterol2026 Oct
  2. Endoscopic diagnosis and management of peptic ulcer bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2026
    Endoscopy2026 Aug
  3. [Evidence-Based Guidelines for the Diagnosis and Treatment of Helicobacter pylori Infection in Korea: 2025 Revised Edition]
    Korean J Gastroenterol2026 Jul 25
  4. Consensus Recommendations for the Management of Helicobacter pylori in Egypt: A 2026 Report
    Dig Dis2026 Jul 7
  5. Evidence-Based Guidelines for the Diagnosis and Treatment of Helicobacter pylori Infection in Korea: 2025 Revised Edition
    Helicobacter2026 Jul-Aug

All papers from the last 12 months

335 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

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  1. Clinical Utility of Anti-reflux Mucosal Intervention for Refractory Gastroesophageal Reflux Disease in Patients With a Hiatal Hernia
    DEN Open2027 AprPMID 42677194
  2. Comparison of Keverprazan-based versus esomeprazole-based dual therapy for initial treatment of Helicobacter pylori infection: a prospective, multicenter, randomized controlled trial
    Ann Med2026 DecPMID 42572417RCT
  3. Efficacy and safety of tegoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: a systematic review and meta-analysis of randomized controlled trials
    Eur J Gastroenterol Hepatol2026 Nov 1PMID 42832287Meta-analysisSystematic review
  4. Distinct molecular effects of vonoprazan and proton pump inhibitors in eosinophilic esophagitis
    Allergol Int2026 Oct 14PMID 42875292
  5. Is Helicobacter pylori Status Responsible for the Altered Pharmacodynamics of Tegoprazan?
    J Gastroenterol Hepatol2026 Oct 14PMID 42870640
  6. 14-Day Keverprazan-Amoxicillin Dual Therapy Versus Bismuth-Containing Quadruple Therapy as First-Line Treatment for Helicobacter pylori Eradication: A Prospective, Single-Center, Randomized Controlled Trial
    J Gastroenterol Hepatol2026 Oct 13PMID 42869649
  7. P-CAB - amoxicillin dual therapy for H. pylori eradication: a narrative review of efficacy, safety, and guideline positioning
    Scand J Gastroenterol2026 Oct 10PMID 42856096Review
  8. Real-world hepatic safety of the potassium-competitive acid blocker: A RUCAM-adjudicated multicenter cohort study
    Clin Gastroenterol Hepatol2026 Oct 9PMID 42854772
  9. Beyond gastric acid: pharmacologic modulation of the tumor microenvironment by vonoprazan and its drug-interaction implications for chemotherapy and immunotherapy
    Cancer Chemother Pharmacol2026 Oct 9PMID 42853402Review
  10. Tegoprazan regulates gut microbiota structure in Helicobacter pylori-induced ulcerative colitis mice
    Folia Microbiol (Praha)2026 Oct 8PMID 42848254

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

vonoprazan[tiab] OR tegoprazan[tiab] OR "potassium-competitive acid blocker*"[tiab]

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.