Ketamine and esketamine for depression
Ketamine and esketamine for treatment-resistant depression.
Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 0, 0, 0, 0, 0.
All papers from the last 12 months
791 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Feasibility and tolerability of virtual reality during esketamine treatment: A pilot studyJ Affect Disord2027 Jan 1PMID 42778030
- Longitudinal peripheral DNA methylation remodeling following ketamine-assisted psychotherapy in major depressive disorderEpigenetics2026 DecPMID 42879530
- Treatments for Individuals with Suicidal Thoughts: Use, Indications, and HelpfulnessJ Affect Disord Rep2026 DecPMID 42808010
- Cognitive effects of ketamine and esketamine treatment for major depressive and bipolar disorder: a systematic reviewPsychiatry Res2026 DecPMID 42762641Systematic reviewReview
- Clinical correlates of non-responders to ketamine in terms of self-assessed life engagement among treatment-resistant depression patientsJ Psychiatr Res2026 DecPMID 42748866
- Beyond symptom reduction: Intranasal esketamine is associated with improved quality of life in treatment-resistant depressionJ Psychiatr Res2026 DecPMID 42731235
- Effects of Esketamine on Postoperative Hospital Anxiety and Depression Scale Scores in Patients Undergoing Laparoscopic Radical Resection for Colorectal CancerJ Invest Surg2026 DecPMID 42723442RCT
- Esketamine vs. sufentanil for quality of recovery after outpatient gynecological surgery: a randomized clinical trialAnn Med2026 DecPMID 42693883RCT
- Intraoperative esketamine for postoperative analgesia and depression in pancreatic cancer surgery: protocol for a multicenter randomized controlled trialAnn Med2026 DecPMID 42657795
- Suicidal ideation covaries with depressive severity during six-month real-world esketamine treatment in a cohort enriched for borderline personality disorderJ Affect Disord2026 Dec 1PMID 42624219
More psychiatry trends
All specialties →Gut microbiome and mental health
Links between the gut microbiome and depression or anxiety.
Psilocybin therapy
Psilocybin-assisted therapy for depression and other conditions.
Brain stimulation for depression
Transcranial magnetic stimulation, including accelerated theta-burst protocols, for depression.
Key point: Connectivity- or frequency- and connectivity-individualized accelerated iTBS failed to yield significant antidepressant benefits over sham stimulation in treatment-resistant depression.
MDMA-assisted therapy
MDMA combined with psychotherapy, mainly studied in PTSD.
Muscarinic antipsychotics
Xanomeline-trospium and other muscarinic drugs for schizophrenia.
Neurosteroids for postpartum depression
Zuranolone and brexanolone for postpartum depression.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
(esketamine[tiab] OR ketamine[tiab]) AND depress*[tiab]Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.