Lupus nephritis
Kidney involvement in lupus and its newer treatments.
Key point
Lupus nephritis management is increasingly individualized, with expanding treatment options, combination therapy, and a trend toward lower corticosteroid doses.
From: KDOQI US Commentary on the KDIGO 2024 Clinical Practice Guideline for the Management of Lupus Nephritis (Am J Kidney Dis, 2026 Aug) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 29, 30, 53, 57, 53.
New guidelines and consensus this year
- Update to the Sociedad Española de Reumatología Guidelines on the Use of Biological Therapy in Systemic Lupus ErythematosusReumatol Clin (Engl Ed)2026 Aug-Sep
- KDOQI US Commentary on the KDIGO 2024 Clinical Practice Guideline for the Management of Lupus NephritisAm J Kidney Dis2026 Aug
- 2025 American College of Rheumatology (ACR) Guideline for the Treatment of Systemic Lupus ErythematosusArthritis Rheumatol2026 Jul
- 2025 American College of Rheumatology (ACR) Guideline for the Treatment of Systemic Lupus ErythematosusArthritis Care Res (Hoboken)2026 Jul
- The 2026 British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosusRheumatology (Oxford)2026 Jun 3
All papers from the last 12 months
1,129 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- A novel urinary metabolic signature for the non-invasive screening of lupus nephritis in systemic lupus erythematosusClin Chim Acta2027 Feb 15PMID 42468728
- Reducing glucocorticoid burden in lupus with omega-3 fatty acids: docosahexaenoic acid augments prednisone efficacy in maintaining cyclophosphamide-induced remission of preclinical lupus nephritisAutoimmunity2026 Dec 31PMID 42733187
- The m6A reader IGF2BP2 promotes proinflammatory signaling in Lupus nephritis by recognizing STAT1 m6A modificationsAutoimmunity2026 Dec 31PMID 42691090
- Targeting IFN signaling as therapeutic option for lupus nephritisAutoimmunity2026 Dec 31PMID 42642989Review
- Integrated bioinformatics reveals tubulointerstitial immune microenvironment signatures and machine learning-driven prognostication of clinical treatment response in lupus nephritisAutoimmunity2026 Dec 31PMID 41928442
- The cGAS-STING pathway in systemic lupus erythematosus and lupus nephritis: a review of novel therapeutic targetsAutoimmunity2026 Dec 31PMID 41560594Review
- Circulating cell-free DNA as a biomarker in systemic lupus erythematosus: A narrative reviewJ Transl Autoimmun2026 DecPMID 42775040Review
- Simultaneous calcified and noncalcified fibrotic splenic nodules in systemic lupus erythematosusRadiol Case Rep2026 DecPMID 42750684
- Rapid early renal response to add-on belimumab in lupus nephritisPediatr Nephrol2026 DecPMID 42334506
- Peritoneal dialysis in lupus nephritis: comparative outcomes vs. hemodialysis, risk stratification, and modality selection frameworkRen Fail2026 DecPMID 42161898Review
More nephrology trends
All specialties →SGLT2 inhibitors in CKD
SGLT2 inhibitors to slow chronic kidney disease.
Key point: In non-diabetic CKD, renin-angiotensin system inhibitors and SGLT2 inhibitors would be indicated as the treatment of choice.
Acute kidney injury biomarkers
Biomarkers to detect and predict acute kidney injury.
IgA nephropathy
IgA nephropathy and the new targeted treatments being studied.
Complement inhibitors in kidney disease
Iptacopan, avacopan and other complement inhibitors in glomerular disease.
Key point: Complement inhibitors had no overall effectiveness or safety advantage over plasma therapy in atypical hemolytic uremic syndrome, except lower relapse rates.
APOL1 kidney disease
Kidney disease linked to APOL1 gene variants.
Home dialysis
Home haemodialysis and peritoneal dialysis.
Key point: Core interventions to reduce PD-related infections focus on surveillance, standardized staff and patient training, infection prevention assessments, and antimicrobial prophylaxis.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
"lupus nephritis"[tiab]Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.