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All general surgery trends
SteadyGeneral surgery · updated 18 Oct 2026

HIPEC and PIPAC

Intraperitoneal chemotherapy for peritoneal metastases.

39PubDaily Trend Score
+10%new papers vs last year
32new trials registered
2new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 35, 21, 21, 27, 32.

New guidelines and consensus this year

  1. Systemic Treatment of Ovarian Cancer Recurrence: ASCO Living Guideline, Version 2026.1.0
    J Clin Oncol2026 Oct
  2. Surgical management of stage IV gastric adenocarcinoma: A systematic review and expert recommendations from the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) and the Spanish Association of Surgeons (AEC)
    Cir Esp (Engl Ed)2026 Feb

All papers from the last 12 months

565 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

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  1. Acute kidney injury after cytoreductive surgery and HIPEC: incidence and timing in a 10-year single-center cohort
    Int J Hyperthermia2026 DecPMID 42449199
  2. Survival and morbidity in elderly patients treated with cytoreductive surgery and HIPEC for colorectal peritoneal metastases: a population-based study
    Int J Hyperthermia2026 DecPMID 41601288
  3. Glucose-containing carriers in cancer therapy (GLUCOSE-ONC): A multistream critical review and quantitative exposure framework
    Neoplasia2026 NovPMID 42785157Review
  4. Determinants of long-term survival vs early failure after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: a comparative analysis of two extreme phenotypes
    J Gastrointest Surg2026 NovPMID 42716462
  5. Plasma-activated solutions potentiate the antitumor effects of HIPEC via endoplasmic reticulum stress mediated apoptosis
    Free Radic Biol Med2026 NovPMID 42600902
  6. Multiple Recurarization Episodes After Sugammadex Reversal in Hyperthermic Intraperitoneal Chemotherapy: A Case Report
    A A Pract2026 Oct 1PMID 42885971
  7. Hematopoietic Stem Cell Transplantation for the Management of Histiocytic Sarcoma: A Case Report and Systematic Review
    Transplant Proc2026 Oct 15PMID 42881046
  8. Anaesthetic implications and occupational safety considerations of pressurised intraperitoneal aerosol chemotherapy procedures: An Australian 5-year single-centre experience
    Anaesth Intensive Care2026 Oct 14PMID 42876201
  9. FRMD6 expression can predict relapse of colorectal carcinoma after cytoreductive surgery with HIPEC
    Biomarkers2026 Oct 14PMID 42837610
  10. The first formulation tailored for intraperitoneal delivery as a pressurised aerosol (PIPAC): doxorubicin-cisplatin as a fixed, ready-to-use drug combination
    Drug Deliv Transl Res2026 Oct 13PMID 42867619

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

HIPEC[tiab] OR "hyperthermic intraperitoneal chemotherapy"[tiab] OR PIPAC[tiab]

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.