Organ preservation in rectal cancer
Total neoadjuvant therapy and watch-and-wait approaches for rectal cancer.
Key point
A higher radiation boost dose was not significantly associated with achieving clinical complete response or durability of organ preservation after total neoadjuvant therapy.
From: Does Radiation Boost Dose Affect Organ Preservation Rates? A Secondary Analysis of the Organ Preservation in Patients With Rectal Adenocarcinoma Trial (Int J Radiat Oncol Biol Phys, 2026 Nov 1) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 20, 28, 33, 58, 63.
New guidelines and consensus this year
- SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2025)Clin Transl Oncol2026 Feb
All papers from the last 12 months
416 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Expanding the ESMO-MCBS: integrating organ preservation into clinical benefit assessment in rectal cancerESMO Gastrointest Oncol2026 DecPMID 42828123
- Consensus recommendations for the management of locally advanced rectal cancerESMO Gastrointest Oncol2026 DecPMID 42787548
- Tertiary lymphoid structures guided opportunities and challenges for immunotherapy in early gastroesophageal junction cancer and low rectal cancerHum Vaccin Immunother2026 DecPMID 41742891Review
- MR imaging of Rectal CancerMagn Reson Imaging Clin N Am2026 NovPMID 42855207Review
- Quality of life and anorectal function in rectal cancer patients undergoing immunotherapy-based total neoadjuvant therapy: a comparison of organ preservation and radical surgeryClin Transl Radiat Oncol2026 NovPMID 42733664
- De-escalated total neoadjuvant therapy for the non-operative management of rectal cancer: Results of the NOM-3/TNT prospective cohort studyClin Transl Radiat Oncol2026 NovPMID 42703503
- Total neoadjuvant therapy for rectal cancer: where are we now, where do we go?Clin Transl Radiat Oncol2026 NovPMID 42604092Review
- Diabetes and Performance Status Predict Severe, Persistent Radiation Proctitis: Long-Term Endoscopic Findings From STELLAR TrialInt J Radiat Oncol Biol Phys2026 Nov 1PMID 42142768RCT
- Does Radiation Boost Dose Affect Organ Preservation Rates? A Secondary Analysis of the Organ Preservation in Patients With Rectal Adenocarcinoma TrialInt J Radiat Oncol Biol Phys2026 Nov 1PMID 42142103RCT
- Oncological impact of adjuvant chemotherapy after rectal cancer excision in the era of FOLFIRINOX-based TNT: A pooled post-hoc analysis of GRECCAR4-PRODIGE23Eur J Cancer2026 Oct 16PMID 42743888RCT
More general surgery trends
All specialties →Antibiotics for appendicitis
Treating uncomplicated appendicitis with antibiotics instead of surgery.
Key point: Non-operative management of acute uncomplicated appendicitis was associated with high long-term failure rates and significant risk of subsequent appendectomy.
ICG fluorescence-guided surgery
Indocyanine green imaging during surgery to assess perfusion and anatomy.
Key point: FIGS with ICG is recommended for detecting non-regional metastases, identifying primary cancers and GI cancer lymph nodes, and assessing esophageal and left-sided colorectal anastomosis quality.
Metabolic and bariatric surgery
Sleeve gastrectomy, gastric bypass and other surgery for obesity and metabolic disease.
Surgical site infection prevention
Measures to prevent infections after surgery.
Mesh in ventral hernia repair
Mesh choice and technique in ventral and incisional hernia repair.
HIPEC and PIPAC
Intraperitoneal chemotherapy for peritoneal metastases.
Too many papers to read?
PubDaily picks the ones that matter in your specialty and summarises them, about 10 minutes a week.
How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
"rectal cancer"[tiab] AND ("total neoadjuvant"[tiab] OR "watch and wait"[tiab] OR "organ preservation"[tiab] OR "nonoperative management"[tiab])Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.