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All ophthalmology trends
RisingOphthalmology · updated 18 Oct 2026

Longer-acting anti-VEGF

Faricimab and high-dose aflibercept for retinal disease.

64PubDaily Trend Score
+55%new papers vs last year
26new trials registered
0new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 3, 9, 13, 20, 26.

All papers from the last 12 months

428 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

Open this search in PubMed
  1. Early high-dose aflibercept 8 mg clinical outcomes in wet age-related macular degeneration patients resistant to aflibercept 2 mg or faricimab
    Acta Ophthalmol2026 NovPMID 42544785
  2. Efficacy of Intravitreal Faricimab for Diabetic Macular Edema and Analysis of Influencing Factors
    Ophthalmologica2026 Oct 16PMID 42886638
  3. When Retention Becomes an Outcome: Disentangling Faricimab Durability and Care Access
    Clin Exp Ophthalmol2026 Oct 16PMID 42885654
  4. When Retention Becomes an Outcome: Disentangling Faricimab Durability and Care Access-Response
    Clin Exp Ophthalmol2026 Oct 15PMID 42880723
  5. Variables Associated With Faricimab Treatment Durability in Neovascular Age-Related Macular Degeneration: A Post Hoc Analysis of the TENAYA and LUCERNE Trials
    JAMA Ophthalmol2026 Oct 15PMID 42879146
  6. Epivascular Glia and Macular Pigment Changes after Faricimab or Aflibercept during the Loading Phase in Diabetic Macular Edema: A Prospective Non-randomized Pilot Study
    Photodiagnosis Photodyn Ther2026 Oct 14PMID 42874754
  7. Switching to faricimab in anti-VEGF-refractory retinal vein occlusion: nine-month prospective real-world outcomes under a modified treat-and-extend regimen
    Graefes Arch Clin Exp Ophthalmol2026 Oct 13PMID 42867512
  8. The Clinical Significance of Polypoidal Lesion Regression in Polypoidal Choroidal Vasculopathy - A Review
    Semin Ophthalmol2026 Oct 11PMID 42860692Review
  9. Study Design for ELARA, a Phase 3b Trial of Aflibercept 8 mg in Previously Treated Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema
    Ophthalmol Ther2026 Oct 9PMID 42853354
  10. Comparative Clinical and Therapeutic Landscape of Aflibercept Biosimilars (YESAFILI), High-Dose Aflibercept 8 mg (EYLEA HD), and Faricimab (VABYSMO): A Structured Narrative Review
    Clin Ophthalmol2026PMID 42866554Review

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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

faricimab[tiab] OR "aflibercept 8"[tiab] OR "high-dose aflibercept"[tiab]

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.