Neoadjuvant therapy in pancreatic cancer
Chemotherapy or chemoradiation before surgery for pancreatic cancer.
Key point
After induction chemotherapy, neoadjuvant chemoradiotherapy is used for borderline tumours to increase chances of complete resection, though survival benefit has not been demonstrated.
From: Radiotherapy of pancreatic cancers: 2025 update (Cancer Radiother, 2025 Nov-Dec) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 35, 27, 37, 31, 44.
New guidelines and consensus this year
- pRECIST: Guidelines for Response Criteria for Use in Trials Testing Therapeutics in Pancreatic CancerPancreas2026 Jul 1
- ACR Appropriateness Criteria® Screening, Locoregional Assessment, and Surveillance of Pancreatic Ductal Adenocarcinoma: 2025 UpdateJ Am Coll Radiol2025 Nov
- Radiotherapy of pancreatic cancers: 2025 updateCancer Radiother2025 Nov-Dec
All papers from the last 12 months
474 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Small-Bowel Impaction Caused by Mechanical Interlocking Between Duodenal Metal and Biliary Plastic StentsDEN Open2027 AprPMID 42318089
- Neoadjuvant quadruplet chemotherapy PAXG for pancreatic cancerLancet2026 Dec 20PMID 41275880
- Impact of center-level protocol adherence on neoadjuvant treatment outcome in pancreatic ductal adenocarcinomaEur J Cancer2026 Oct 16PMID 42743889RCT
- When to Operate After Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer: A Critical Review and Multidimensional Decision FrameworkJ Gastrointest Surg2026 Oct 14PMID 42874796Review
- Routine H&E Histology Encodes Postoperative Risk Heterogeneity in Resected Pancreatic Ductal Adenocarcinoma: A Multicohort Evaluation of TIGERSMod Pathol2026 Oct 14PMID 42874742
- Limited Survival Benefit of Short-Course Neoadjuvant Gemcitabine Plus Nab-Paclitaxel for Resectable Pancreatic Cancer: A Prospective Phase II Study With a Propensity Score-Matched AnalysisJ Surg Res2026 Oct 14PMID 42874369
- Driver mutation profiling by next-generation sequencing predicts survival and recurrence after curative-intent resection for pancreatic ductal adenocarcinoma: a genomic cohort studyClin Transl Oncol2026 Oct 13PMID 42870132
- MRI for restaging pancreatic cancerInsights Imaging2026 Oct 13PMID 42867719
- Predictive Factors for Occult Metastases in Clinically M0 Pancreatic Cancer: A Prospective Multicenter Analysis of Staging LaparoscopyAnn Surg Oncol2026 Oct 13PMID 42867593
- Clinical Efficacy of Tislelizumab Plus Gemcitabine-Nab-Paclitaxel for Borderline Resectable Pancreatic Cancer and Chemoresistance Analysis: A Prospective Pilot StudyAnn Surg Oncol2026 Oct 12PMID 42862523
More general surgery trends
All specialties →AI and surgical video
Computer vision and AI applied to surgical video and intraoperative decisions.
Robotic general surgery
Robot-assisted cholecystectomy, hernia repair and colorectal surgery.
Key point: Robotic-assisted surgery was associated with a modestly shorter hospital stay and similar complications, readmissions, and reoperations versus laparoscopy in obese colorectal cancer patients.
Prehabilitation
Exercise, nutrition and psychological preparation before surgery.
Antibiotics for appendicitis
Treating uncomplicated appendicitis with antibiotics instead of surgery.
Key point: Non-operative management of acute uncomplicated appendicitis was associated with high long-term failure rates and significant risk of subsequent appendectomy.
ICG fluorescence-guided surgery
Indocyanine green imaging during surgery to assess perfusion and anatomy.
Key point: FIGS with ICG is recommended for detecting non-regional metastases, identifying primary cancers and GI cancer lymph nodes, and assessing esophageal and left-sided colorectal anastomosis quality.
Metabolic and bariatric surgery
Sleeve gastrectomy, gastric bypass and other surgery for obesity and metabolic disease.
Too many papers to read?
PubDaily picks the ones that matter in your specialty and summarises them, about 10 minutes a week.
How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
("pancreatic cancer"[tiab] OR "pancreatic ductal adenocarcinoma"[tiab]) AND neoadjuvant[tiab]Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.