Opioid-free anaesthesia
Anaesthesia techniques that avoid or minimise intraoperative opioids.
Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 46, 37, 47, 56, 121.
All papers from the last 12 months
722 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Ultrasound-Guided Dorsal Penile Nerve Block Reduces Perioperative Opioid Requirements in Pediatric Circumcision: A Systematic Review and Meta-AnalysisJ Invest Surg2026 DecPMID 42820467Meta-analysisSystematic review
- Pre-operative narcotic use is associated with worse outcomes following primary anatomic and reverse shoulder arthroplastyJ Shoulder Elb Arthroplast2026 DecPMID 42774874
- Liposomal bupivacaine versus ropivacaine for surgical site infiltration in lumbar fusion: a prospective randomized controlled trialAnn Med2026 DecPMID 42504098RCT
- Virtual reality for opioid reduction in postoperative cardiac and thoracic surgery: A randomized controlled trial protocolMethodsX2026 DecPMID 42438674
- Transcutaneous auricular vagus nerve stimulation combined with ciprofol for sedation in patients undergoing same-session bidirectional endoscopy: a randomized, double-blind, placebo-controlled, three-arm non-inferiority trial protocolAnn Med2026 DecPMID 42384896
- Thoracic paravertebral block with different doses of liposomal bupivacaine versus ropivacaine for postoperative analgesia in single-port thoracoscopic lung surgery: a randomized clinical trialAnn Med2026 DecPMID 42342240RCT
- Advances in Ultrasound-Guided Fascial Plane Blocks for Perioperative Acute Pain ManagementJ Invest Surg2026 DecPMID 42262005Review
- Advances in ERAS to Reduce the Incidence of Chronic Post-Surgical Pain and Persistent Postoperative Opioid Use: A Narrative ReviewJ Invest Surg2026 DecPMID 42138101Review
- Response to letter regarding enhancing the evidence for opioid-free anaesthesia in the elderly: a call for methodological clarityAnn Med2026 DecPMID 41940455
- Enhancing the evidence for opioid-free anaesthesia in the elderly: a call for methodological clarityAnn Med2026 DecPMID 41821494
More anesthesiology trends
All specialties →GLP-1 drugs and perioperative aspiration
Delayed gastric emptying with GLP-1 based medicines and the risk at anaesthesia.
Key point: GLP-1 RA-based therapies should continue in most patients, with individualized risk assessment and gastric ultrasound when delayed gastric emptying is suspected.
Liposomal bupivacaine
Studies of liposomal bupivacaine for postoperative analgesia and regional blocks.
Intraoperative hypotension
Low blood pressure during surgery and its effects on outcomes.
Key point: In adults undergoing elective noncardiac surgery, targeting higher intraoperative blood pressure values does not improve major postoperative outcomes compared with routine management.
Postoperative delirium
Acute confusion after surgery, its prevention and outcomes.
Fascial plane blocks
Regional blocks such as the erector spinae plane and quadratus lumborum blocks.
Key point: For adults, fascial plane blocks are strongly recommended to reduce pain and/or opioid requirements after open cardiothoracic, abdominal, retroperitoneal, pelvic surgeries and mastectomy.
EEG-guided anaesthesia
Processed EEG monitoring to guide anaesthetic depth.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
"opioid-free anesthesia"[tiab] OR "opioid-free anaesthesia"[tiab] OR "opioid-sparing"[tiab]Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.