Buprenorphine started in the ED

Tranexamic acid in trauma and other acute haemorrhage.

Key point: Tranexamic acid does not affect all-cause mortality, functional outcomes, neurological impairment, or hematoma expansion in spontaneous intracerebral hemorrhage, despite reducing hematoma volume.

Video laryngoscopes for tracheal intubation.

Key point: For neonatal and infant airway management, videolaryngoscopy is the first choice for intubation, with apneic oxygenation during the attempt.

Using ECMO during cardiac arrest when conventional CPR fails.

Key point: Extracorporeal CPR may be considered for selected in-hospital pediatric arrests unresponsive to conventional CPR in appropriately resourced hospitals, with insufficient evidence for out-of-hospital use.

Resuscitative endovascular balloon occlusion of the aorta for major haemorrhage.

Ketamine for analgesia, sedation and intubation in the ED and before hospital.

Key point: Sentinel adverse events were extremely rare, strongly supporting the safety of ED ketamine for procedural sedation of children.

Comparing balanced solutions such as lactated Ringer's with normal saline for fluid therapy.

Key point: Balanced crystalloid policies were not associated with a clear reduction in mortality or acute kidney injury in cluster-randomized evaluations of routine care.