Tranexamic acid in bleeding
Tranexamic acid in trauma and other acute haemorrhage.
Key point
Tranexamic acid does not affect all-cause mortality, functional outcomes, neurological impairment, or hematoma expansion in spontaneous intracerebral hemorrhage, despite reducing hematoma volume.
From: Tranexamic acid in spontaneous intracerebral hemorrhage: an updated systematic review and meta-analysis of randomized controlled trials (Ann Med, 2026 Dec) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 21, 26, 22, 20, 37.
New guidelines and consensus this year
All papers from the last 12 months
386 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- A multifunctional injectable hemostatic hydrogel for sustained tranexamic acid delivery and ROS attenuation in intracerebral hemorrhageBiomater Adv2027 JanPMID 42748888
- Tranexamic acid in spontaneous intracerebral hemorrhage: an updated systematic review and meta-analysis of randomized controlled trialsAnn Med2026 DecPMID 41777112Meta-analysisSystematic review
- Surgical management of a plexiform neurofibroma in neurofibromatosis type 1: The haemostatic challengeJPRAS Open2026 NovPMID 42733612
- Tranexamic acid is associated with thrombosis and reoperation of vascular reconstructions for lower extremity arterial injuriesJ Vasc Surg2026 NovPMID 42285185
- Acute hemorrhagic shock from vaginal laceration during intercourse requiring operative managementAm J Emerg Med2026 Oct 11PMID 42874252
- The feast of prisoners: Confining drugs and inflammatory factors locally in tumorsJ Control Release2026 Oct 10PMID 42508770
- Survival benefit of prehospital TXA in fibrinolytic shutdown: Insights from two prospective trauma trialsJ Trauma Acute Care Surg2026 Oct 9PMID 42853261
- Refractory Status Epilepticus Following Erroneous Intrathecal Injection of Tranexamic Acid: A Case Report and Long-Term Follow-Up and Narrative ReviewCase Rep Anesthesiol2026PMID 42851974
- A biomimetic electrospun collagen/chitosan nanofiber membrane for topical delivery of tranexamic acidInt J Biol Macromol2026 Oct 8PMID 42849392
- In vitro correction of venom-induced coagulopathy in Daboia russelii envenomation demonstrated using tranexamic acid-modified rotational thromboelastometryBMJ Case Rep2026 Oct 7PMID 42843908
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REBOA
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
"tranexamic acid"[tiab] AND (trauma*[tiab] OR emergency[tiab] OR hemorrhag*[tiab] OR haemorrhag*[tiab])Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.