Dexmedetomidine
Dexmedetomidine for sedation, analgesia and delirium prevention.
Key point
In mechanically ventilated patients with sepsis and septic shock, dexmedetomidine shortened mechanical ventilation but increased bradycardia risk, without mortality or organ dysfunction benefits.
From: The effect of dexmedetomidine in mechanically ventilated patients with sepsis and septic shock: a meta-analysis of randomized controlled trials (Ann Med, 2026 Dec) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 167, 207, 206, 246, 272.
All papers from the last 12 months
1,327 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Respiratory Support With Nasal High Flow Reduces Opioid Requirements During Endoscopic Retrograde CholangiopancreatographyDEN Open2027 AprPMID 42699223
- Dexmedetomidine induces bradycardia through vagal-nucleus tractus solitarius glutamatergic circuitNeuropharmacology2026 Dec 15PMID 42749214
- Statement of Retraction: Dexmedetomidine protects H9C2 rat cardiomyocytes against hypoxia/reoxygenation injury by regulating the long non-coding RNA colon cancer-associated transcript 1/microRNA-8063/Wnt/β-catenin axisBioengineered2026 DecPMID 42821488
- Opioid-free analgesia with esketamine-dexmedetomidine versus opioid-based analgesia after gynaecological laparoscopic surgery: a double-blind, randomized, controlled trialAnn Med2026 DecPMID 42745658RCT
- Effects of erector spinae plane block on postoperative pain in patients undergoing implant-based breast reconstruction for breast cancer: a randomized controlled trialAnn Med2026 DecPMID 42686359RCT
- Bradycardia associated with dexmedetomidine in critically ill patients: A retrospective study of risk factors and clinical outcomesJ Crit Care2026 DecPMID 42531899
- Remimazolam for sedation in flexible bronchoscopy: A systematic review and meta-analysis of randomised controlled trialsPulmonology2026 DecPMID 42313074Meta-analysisSystematic review
- The effect of dexmedetomidine in mechanically ventilated patients with sepsis and septic shock: a meta-analysis of randomized controlled trialsAnn Med2026 DecPMID 41846301Meta-analysisSystematic review
- Letter to editor regarding 'Dexmedetomidine nasal spray for patients undergoing endoscopic retrograde cholangiopancreatography: protocol for a randomized controlled trial'Ann Med2026 DecPMID 41736481
- Dexmedetomidine nasal spray for patients undergoing endoscopic retrograde cholangiopancreatography: protocol for a randomized controlled trialAnn Med2026 DecPMID 41607082
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Remimazolam
An ultra-short-acting benzodiazepine for sedation and anaesthesia.
Key point: Remimazolam is a safe and effective alternative for bronchoscopy sedation, offering improved cardiopulmonary safety and favourable procedural characteristics.
Perioperative esketamine
Esketamine for analgesia and mood around surgery.
Key point: Intraoperative low-dose esketamine improved early patient-reported recovery after minimally invasive esophagectomy by enhancing analgesia and reducing postoperative anxiety and depression without increasing adverse events.
Environmental impact of anaesthesia
The climate footprint of volatile anaesthetics and nitrous oxide.
Sugammadex
Reversal of neuromuscular blockade with sugammadex.
Gastric ultrasound
Point-of-care ultrasound of stomach contents before anaesthesia.
Key point: Preanesthetic gastric ultrasound provides a practical bedside method for assessing gastric content and estimating aspiration risk in patients undergoing anesthesia.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
dexmedetomidine[tiab]Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.