Perioperative esketamine
Esketamine for analgesia and mood around surgery.
Key point
Intraoperative low-dose esketamine improved early patient-reported recovery after minimally invasive esophagectomy by enhancing analgesia and reducing postoperative anxiety and depression without increasing adverse events.
From: Effects of low-dose esketamine on early quality of recovery following minimally invasive esophagectomy: a multicenter, randomized controlled study (Ann Med, 2026 Dec) ↗Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 29, 27, 34, 34, 35.
All papers from the last 12 months
283 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Opioid-free analgesia with esketamine-dexmedetomidine versus opioid-based analgesia after gynaecological laparoscopic surgery: a double-blind, randomized, controlled trialAnn Med2026 DecPMID 42745658RCT
- Effects of Esketamine on Postoperative Hospital Anxiety and Depression Scale Scores in Patients Undergoing Laparoscopic Radical Resection for Colorectal CancerJ Invest Surg2026 DecPMID 42723442RCT
- Esketamine vs. sufentanil for quality of recovery after outpatient gynecological surgery: a randomized clinical trialAnn Med2026 DecPMID 42693883RCT
- Intraoperative esketamine for postoperative analgesia and depression in pancreatic cancer surgery: protocol for a multicenter randomized controlled trialAnn Med2026 DecPMID 42657795
- Effects of low-dose esketamine on early quality of recovery following minimally invasive esophagectomy: a multicenter, randomized controlled studyAnn Med2026 DecPMID 42484088RCT
- Effects of sub-anesthetic doses of esketamine on immune function and postoperative negative emotions in acoustic neuroma patients: a randomized clinical trialAnn Med2026 DecPMID 42396903RCT
- Perioperative Ketamine and Esketamine for Enhanced Recovery After Surgery (ERAS): A Systematic ReviewJ Invest Surg2026 DecPMID 41814842Systematic review
- Letter regarding "efficacy of esketamine in reducing nausea and vomiting after anesthesia: a systematic review and meta-analysis of randomized controlled trials"Ann Med2026 DecPMID 41663054
- Letter to the editor regarding: Efficacy of esketamine in reducing nausea and vomiting after anesthesia: a systematic review and meta-analysis of randomized controlled trialsAnn Med2026 DecPMID 41630466
- Effects of nine sedative-analgesic combinations on fatigue after gastrointestinal endoscopy: a randomized controlled 3 × 3 factorial trial protocolAnn Med2026 DecPMID 41607108
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
esketamine[tiab] AND (postoperative[tiab] OR perioperative[tiab] OR anesthesia[tiab] OR anaesthesia[tiab])Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.