Polypharmacy
Use of many medicines at once and its risks.
Papers per year
Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 36, 48, 34, 44, 62.
New guidelines and consensus this year
- Pharmacological treatment strategies to prevent heart failure across the cardiovascular-kidney-metabolic spectrum: an EJHF Expert Consensus StatementEur J Heart Fail2026 Oct 1
- [Geriatric assessments and their practical application in uro-oncology : How do we decide on prostate cancer treatment in an age-appropriate way?]Urologie2026 Oct
- A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholdersInt J Clin Pharm2026 Sep 3
- Generative AI in the Care of Older Adults: A Position Statement From the American Geriatrics SocietyJ Am Geriatr Soc2026 Jul 21
- Deprescribing in Older People: A Clinical Practice Guideline SummaryMed J Aust2026 Apr
All papers from the last 12 months
2,388 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…
- Comorbidity and polypharmacy burden among people living with HIV in the United States stratified by age, sex, and race: updated evidence from a contemporary cohortHIV Res Clin Pract2026 Dec 31PMID 42735234
- Antidepressant effects of facial botulinum toxin a injections: Insights from randomized controlled trialsJ Affect Disord2026 Dec 15PMID 42669382Meta-analysisSystematic review
- Rapid screening of physicochemical compatibility between co-administered injectable drugs using thermal and spectroscopic approachesJ Pharm Biomed Anal2026 Dec 15PMID 42546540
- Gut microbiota in patients receiving dialysis: Mechanisms, complications and the road to personalized microbiome‑based care (Review)Mol Med Rep2026 DecPMID 42885316Review
- Characterising pharmacist interventions from person-centred medicines reviews in general practice settingsExplor Res Clin Soc Pharm2026 DecPMID 42787765
- Potential interactions between creatine supplementation and prescription drugs: a narrative review and evidence-mapping perspectiveCurr Ther Res Clin Exp2026 DecPMID 42757020Review
- Polypharmacy status and its related risk factors among elderly patients with dyslipidemia: Iranian multi-center osteoporosis study (IMOS) 2021J Diabetes Metab Disord2026 DecPMID 42719230
- Kidney injury associated with direct oral anticoagulants: a comparative study of direct thrombin inhibitors and factor Xa inhibitors based on literature and database analysisRen Fail2026 DecPMID 42717832
- Longitudinal dynamics of frailty in older people: Trajectories, transitions and associated clinical factorsArch Gerontol Geriatr2026 DecPMID 42669283
- Medication safety in older adults in India: an integrative PhD synthesis of direct evidence and contextual implementation evidenceGlob Health Action2026 DecPMID 42605781Systematic review
More internal medicine trends
All specialties →Cardiovascular-kidney-metabolic syndrome
The linked burden of cardiovascular disease, kidney disease, diabetes and obesity.
Large language models in clinical care
Chatbots and large language models used for clinical questions, documentation and patient communication.
GLP-1 drugs for obesity
GLP-1 based medicines such as semaglutide and tirzepatide for weight management.
Frailty assessment
Tools and scores to identify frailty in older adults.
Deprescribing
Planned reduction or stopping of medicines that may no longer benefit the patient.
Key point: Deprescribing statins is suggested for older adults at end of life; continuation is suggested for primary or secondary prevention otherwise.
Hospital at home
Acute hospital-level care delivered in the patient's home.
Key point: Home hospitalization presents an effective strategy for comprehensive heart failure management, reducing hospital-related complications and promoting patient-centered care.
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How these numbers are counted
PubMed query, searched in titles and abstracts by publication date:
polypharmacy[tiab]Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.