What internal medicine is researching now
The topics gaining the most ground, ranked by the PubDaily Trend Score: new research, stronger evidence, new trials and new guidelines. 291 topics in 22 specialties, updated 18 Oct 2026.
Monthly reportThe fastest-rising topics in medicine: October 2026Read →Cardiovascular-kidney-metabolic syndrome
The linked burden of cardiovascular disease, kidney disease, diabetes and obesity.
Large language models in clinical care
Chatbots and large language models used for clinical questions, documentation and patient communication.
GLP-1 drugs for obesity
GLP-1 based medicines such as semaglutide and tirzepatide for weight management.
Polypharmacy
Use of many medicines at once and its risks.
Frailty assessment
Tools and scores to identify frailty in older adults.
Deprescribing
Planned reduction or stopping of medicines that may no longer benefit the patient.
Key point: Deprescribing statins is suggested for older adults at end of life; continuation is suggested for primary or secondary prevention otherwise.
See all 12 internal medicine topics
Every rising topic, with the papers behind it. Free for doctors.
How the Trend Score works
Four signals
Growth in new papers (35%), growth in randomised trials, meta-analyses and systematic reviews (25%), new clinical trials registered (20%), and new guidelines and consensus statements (20%), each over the last 12 months against the 12 before.
A score out of 100
Each signal is ranked against every topic we follow, so a score of 90 means the topic is ahead of about 90% of them. Rising fast: 80 and above. Rising: 55 to 79. Emerging: fewer than 100 papers the year before, too few to rank.
What it does not tell you
More research on a topic is not evidence that a treatment works. Open a topic to read the papers and guidelines themselves. Counts come from PubMed and ClinicalTrials.gov.