Sign up
Research trends

What internal medicine is researching now

The topics gaining the most ground, ranked by the PubDaily Trend Score: new research, stronger evidence, new trials and new guidelines. 291 topics in 22 specialties, updated 18 Oct 2026.

Monthly reportThe fastest-rising topics in medicine: October 2026Read →
12 topics · internal medicine

Cardiovascular-kidney-metabolic syndrome

Rising fast
+153%new papersScore 98
20212026

The linked burden of cardiovascular disease, kidney disease, diabetes and obesity.

1,111 papers / yr21 new trials8 new guidelines
See all papers →

Large language models in clinical care

Rising fast
+45%new papersScore 91
20212026

Chatbots and large language models used for clinical questions, documentation and patient communication.

7,079 papers / yr183 new trials12 new guidelines
See all papers →

GLP-1 drugs for obesity

Rising fast
+60%new papersScore 90
20212026

GLP-1 based medicines such as semaglutide and tirzepatide for weight management.

3,169 papers / yr344 new trials19 new guidelines
See all papers →

Polypharmacy

Rising fast
+40%new papersScore 81
20212026

Use of many medicines at once and its risks.

2,388 papers / yr62 new trials8 new guidelines
See all papers →

Frailty assessment

Rising
+35%new papersScore 72
20212026

Tools and scores to identify frailty in older adults.

4,340 papers / yr421 new trials19 new guidelines
See all papers →

Deprescribing

Rising
+49%new papersScore 70
20212026

Planned reduction or stopping of medicines that may no longer benefit the patient.

Key point: Deprescribing statins is suggested for older adults at end of life; continuation is suggested for primary or secondary prevention otherwise.

731 papers / yr0 new trials9 new guidelines
See all papers →

See all 12 internal medicine topics

Every rising topic, with the papers behind it. Free for doctors.

How the Trend Score works

Four signals

Growth in new papers (35%), growth in randomised trials, meta-analyses and systematic reviews (25%), new clinical trials registered (20%), and new guidelines and consensus statements (20%), each over the last 12 months against the 12 before.

A score out of 100

Each signal is ranked against every topic we follow, so a score of 90 means the topic is ahead of about 90% of them. Rising fast: 80 and above. Rising: 55 to 79. Emerging: fewer than 100 papers the year before, too few to rank.

What it does not tell you

More research on a topic is not evidence that a treatment works. Open a topic to read the papers and guidelines themselves. Counts come from PubMed and ClinicalTrials.gov.