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All internal medicine trends
SteadyInternal medicine · updated 18 Oct 2026

Long COVID

Symptoms persisting or appearing after acute SARS-CoV-2 infection.

Key point

Evidence-based recommendations suggest vaccination or antivirals during acute COVID-19 to prevent long COVID, but certainty is very low to moderate.

From: Clinical practice guideline for long COVID prevention and treatment (Eur Respir J, 2026 Jul) ↗
25PubDaily Trend Score
-17%new papers vs last year
79new trials registered
2new guidelines this year

Papers per year

Each bar is 12 months; the last one ends 17 Oct 2026. New trials in the same years: 195, 247, 154, 97, 79.

New guidelines and consensus this year

  1. Clinical practice guideline for long COVID prevention and treatment
    Eur Respir J2026 Jul
  2. Clinical Practice Guideline Recommendations for Post-Acute Sequelae of COVID-19
    Infect Chemother2025 Dec

All papers from the last 12 months

4,081 papers (18 Oct 2025 – 17 Oct 2026), newest first. Loading the full list…

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  1. Pandemic research in a small island society-a narrative review of research contributions during the SARS-CoV-2 pandemic in the Faroe Islands
    Int J Circumpolar Health2026 Dec 31PMID 42684387Review
  2. Gut microbiome signatures during acute infection are associated with long COVID
    Gut Microbes2026 Dec 31PMID 42615987
  3. Towards ending tuberculosis in South Africa: an uncertainty analysis of the programmes and factors most critical to future declines
    Glob Health Action2026 Dec 31PMID 42609173
  4. Eighty years of postwar multilateralism: Global health law's emergence and its contemporary challenges
    Glob Public Health2026 Dec 31PMID 42312797
  5. Persistent Immune Thrombocytopenia as a Post-Acute Sequelae of COVID-19: A Case Report
    Public Health Chall2026 DecPMID 42845832
  6. Post-COVID-19 Public Health Challenges: Insights Into Post-COVID Symptoms, Stigma, and Post-Pandemic Recovery Support From the Vietnam Experience
    Public Health Chall2026 DecPMID 42831069
  7. The post-acute effects of COVID-19 are not associated with robust long-term regional or global brain volumetric changes: A Bayesian meta-analytic evidence
    Neurosci Biobehav Rev2026 DecPMID 42767409Meta-analysisReview
  8. Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study
    Neuroimage Rep2026 DecPMID 42761604
  9. Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC)
    Expert Rev Vaccines2026 DecPMID 42755271
  10. CBT-informed care for long COVID: Current evidence and priorities for future research
    J Psychosom Res2026 DecPMID 42749526

More internal medicine trends

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Deprescribing

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+49%new papersScore 70
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Planned reduction or stopping of medicines that may no longer benefit the patient.

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Hospital at home

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+20%new papersScore 54
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Acute hospital-level care delivered in the patient's home.

Key point: Home hospitalization presents an effective strategy for comprehensive heart failure management, reducing hospital-related complications and promoting patient-centered care.

220 papers / yr14 new trials1 new guideline
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Remote patient monitoring

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+11%new papersScore 50
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Tracking patients' vital signs and symptoms at home with connected devices.

Key point: Remote monitoring is a standard tool for managing patients with cardiac implantable electronic devices, offering early event detection, fewer routine visits, and reduced mortality.

1,507 papers / yr200 new trials9 new guidelines
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Hyponatremia

Steady
+16%new papersScore 50
20212026

Low blood sodium, its causes and correction.

Key point: Hyponatremia in cirrhosis should be worked up with dietary and medication history, electrolyte/kidney review, bleeding and infection assessment, and thyroid/adrenal evaluation.

1,025 papers / yr24 new trials1 new guideline
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Social determinants of health

Steady
+5%new papersScore 46
20212026

Social and economic conditions that shape health outcomes.

4,252 papers / yr74 new trials10 new guidelines
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Intravenous iron

Steady
+10%new papersScore 39
20212026

Intravenous iron formulations for iron deficiency.

Key point: In chronic kidney disease, transferrin saturation and ferritin thresholds guide iron therapy, with intravenous iron preferred over oral iron in people receiving hemodialysis.

370 papers / yr30 new trials6 new guidelines
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How these numbers are counted

PubMed query, searched in titles and abstracts by publication date:

"long COVID"[tiab] OR "post-COVID"[tiab] OR "post-acute sequelae"[tiab] OR PASC[tiab]

Trials: ClinicalTrials.gov studies first submitted in each 12-month window that match the same terms. A query can miss synonyms or catch unrelated papers, so treat counts as approximate.